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Geroprotective and Anticarcinogenic Activity Lifetime Murine Studies Long-term studies in mice demonstrated that DSIP administration over a lifetime decreased total spontaneous tumour incidence 2.6-fold compared to untreated controls, slowed age-related switching-off of oestrous function, decreased the frequency of chromosome aberrations in bone marrow cells by 22.6%, and increased maximum lifespan by 24.1% compared to control groups a multi-parameter geroprotective profile that is among the most striking reported for any short regulatory peptide, and that has generated sustained interest in the DSIP analogue research field

Loren Pickart, Anna Margolina: Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

This aggressive first-pass effect leaves very little intact NAC to circulate systemically to the brain or peripheral muscles

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Additionally, both SF-36 PCS and ESR tended to correlate with serum GPX-3 concentration simultaneously but the correlation was not statistically significant (Table 2)

doi: 10.1016/S0891-5849(01)00724-9 84 LiuJJLiuQWeiHLYiJZhaoHSGaoLP