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It is further theorized that these high calcium concentrations within the cell could prompt the secretory vesicles in the somatotroph cells to release growth hormone into the bloodstream
Current evidence from large cardiovascular outcome trials and regulatory reviews does not support a direct link between GLP-1 agonists and thrombotic events
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However, these results are preliminary and suggest a need for further exploration
In the ATTAIN-MAINTAIN trial, switching from injectable Mounjaro to oral Foundayo preserved 74.7% of weight loss over a year, and switching from injectable Wegovy preserved 79.3%
If ePA leads to more patients receiving GLP-1 therapy on schedule (versus some patients dropping after a difficult manual PA), then short-term costs might rise
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