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This research was supported by National Natural Science Foundation of China (82271112)
A 2025 review in The Journal of Clinical Endocrinology & Metabolism explains that GLP-1 receptor agonists slow gastric emptying and small-intestinal motility, which is part of how they affect blood sugar and post-meal metabolism
The improvements in insulin sensitivity attributed to tirzepatide were only partly explained by weight loss, suggesting that the dual receptor agonism of tirzepatide provides distinct mechanisms for glycemic control beyond weight reduction
After the 8 weeks, participants were allowed to gradually introduce their normal foods back into the diets to stabilize their weight
3.2 Peripheral GLP-1 signalling in taste pathways: cellular plausibility and translational limits Preclinical studies indicate that GLP-1 is produced in distinct subpopulations of mammalian taste bud cells (TBCs) (13), including TAS1R3-positive and gustducin-positive type II cells, as well as a subset of serotonin-containing type III cells (38)
2B) [39]
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