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The 2021 Frontiers in Pharmacology review compiled the wound-healing literature across multiple tissue categories (PMID 34267654)
Overall the changes are best regarded as a lentigo maligna (Hutchinson's melanotic freckle)
Psoriasis, a chronic immune-mediated skin disease affecting all age groups globally, was chosen as the model due to its significant individual and societal burden, including associated psychosocial comorbidities like anxiety and depression 38,39,40
Together, these findings position NRF2 as the central mediator of melatonin-induced metabolic reprogramming and functional suppression in ILC2s and identify NRF2 as a therapeutically actionable target
Table 2 gives an overview of the characteristics and results of the entire SURPASS study program (6974)
