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Neuroscience Applied

To elucidate the role of GLP-1Rs in the LS in mediating the anorexigenic effects of liraglutide, we used CRISPR/Cas9 technology to specifically knock down GLP-1R expression in LS GLP-1R neurons

OSA seems to be more common with increasing disease severity [50], indicating that it should perhaps be proactively evaluated for in uncontrolled asthmatics [51]

New Gallup data shows that 12.4% of American adults now report using drugs like Ozempic and Wegovy for weight loss, more than double the share from early 2024 and driven largely by middle-aged adults

Stronger effects observed in older adult populations may reflect unique pathophysiological mechanisms of late-life depression, including mitochondrial dysfunction and neurodegenerative processes, which ALC could plausibly target

Significant weight loss from tirzepatide may reduce levothyroxine requirements in some patients, necessitating TSH monitoring at baseline, after substantial weight loss, and every 6-12 months once stable