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Achievement of normal liver fat content (less than 5%) occurred in 27% of participants receiving 1 mg, 52% receiving 4 mg, 79% receiving 8 mg, and 86% receiving 12 mg at 24 weeks, compared to 0% with placebo

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Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, et al

Persistently activated NRF2 drives malignant progression of cancers by increasing therapeutic resistance and promoting aggressive tumorigenesis, a state termed as NRF2 addiction