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If a patient reports persistent injection site discomfort that is not resolving within 24 to 48 hours, copper sensitivity is the first thing we evaluate

For the other three components, validated human values are lacking

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thaliana MS isoforms have a variable number of cysteine residues, but only three of them are conserved, including the two zinc-binding cysteines (Figure 4 and Supplementary Table 5)

It means clinicians and patients must make decisions under uncertainty