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The major cardiovascular safety trials The SUSTAIN-6 trial enrolled 3,297 patients with type 2 diabetes and high cardiovascular risk, following them for two years on semaglutide 0.5 mg or 1.0 mg weekly versus placebo

The main rationale is that targeting multiple pathways would improve efficacy and therapeutic index 56

Amyloidosis in Alzheimer's disease: pathogeny, etiology, and related therapeutic directions

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Eli Lilly and Company TRANSCEND-T2D-1 (June 2026, ADA 86th Scientific Sessions): Results were simultaneously published in The Lancet