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Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)

For instance, Angiogenesis is promoted by HIF-1 to stimulate the vascular endothelial growth factor (VEGF) pathway in gastric cancer (79)