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While Ive lost weight, Im also thankful its helped with my food noise, energy, and inflammation
To date, studies have cast doubt on whether patients who stop taking the drugs can keep off the weight long-term
Additionally, questions exist about potential effects in this population, including the impact of rapid weight loss on skin elasticity and lymphatic function in areas already affected by tissue changes
The oxidative stress benefits of any calorie limitation make mood benefits unsurprising
3,5 In early T2DM managed with lifestyle alone, orforglipron lowered glycated hemoglobin A1c (HbA1c) by -1.24 to -1.48 percentage points over 40 weeks as compared to -0.41 with placebo, with no severe hypoglycemia reported and weight reduction ranging from 4.5% to 7.6%, 3 which led to mean HbA1c levels of 6.5-6.7%
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