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Administration of DSS in drinking water also resulted in the induction of a reproducible pro-inflammatory response, limited to the colon and characterized by lesions, loss of crypts, and infiltration of granulocytes, similar to PGN administration (Okayasu et al

doi: 10.1080/19490976.2020.1737307 29 DerrienM.ColladoM

Now, even as supply stabilizes and FDA shortage designations are lifted, compounded versions remain active in the market, raising critical questions around regulatory oversight, market sustainability, and long-term implications for branded manufacturers