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Our PRE experiments suggest that hydrophobic interactions play a crucial role in the interaction between FOXO4 FHD and p53 TAD

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Ozempic may transfer into breast milk, and experts advise against use during lactation due to unknown effects on infant development

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Bispecific molecules are more often designed to target antigens expressed on the same cell or cells within the same environment but our data also demonstrates the feasibility of achieving dual pharmacology when targeting molecules in very different compartments: a soluble serum protein (PCSK9) and a GPCR predominately expressed in pancreatic -cells (GLP-1R)