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Albers, J
Longer-term liraglutide administration at the highest dose approved for obesity increases reward-related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti-obesity therapies
The best non-diabetic body-composition anchor favors tirzepatide, about 75:25 fat-to-lean loss in its DXA data versus about 62:38 in semaglutides. This is cross-trial evidence, not a head-to-head maintenance-dose DXA result
For a peptide like tirzepatide, freezing is also not recommended but some formulations tolerate it briefly
The principal changes are as follows: GHK-Cu for non-injectable routes of administration is being removed from Category 1, and GHK-Cu for injectable routes of administration is separately being removed from Category 2
It is not an FDA-approved generic
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