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Glucagon receptor activation pushes energy expenditure and hepatic lipid handling in ways the single-target drugs do not
Presented for research literature review only The Lancet Regional Health-Europe (2024)
Such cardiometabolic risk factors, the most widely recognised of which include dyslipidaemia, hypertension and elevated plasma glucose, have been shown to promote the development of atherosclerotic cardiovascular disease (ASCVD)
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Exception : Saxagliptin has been associated with an increased risk of hospitalisation for heart failure (SAVOR-TIMI 53 trial), and should be avoided in patients with established HF or high HF risk