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4433-A STABILIZATION OF O-GLCNACYLATION INCREASES EZH2 DIRECT TARGETS IN HEPATOCELLULAR CARCINOMA Margot Thirion 1 , Coline Kerbaj 1 , Marie-Laure Plissonnier 1 , Massimiliano Cocca 1 , Vincenzo Alfano 1 , Francesca Guerrieri 1 , Claude Caron De Fromentel 1 , Massimo Levrero 1,2 and Mirjam B
doi: 10.3389/fphar.2014.00196 9 Arancibia-HernndezY
The HFD feeding was suggested to induce HDAC3 activity, which was associated with increased body weight gain and blood glucose concentrations ( Figure 2 ), while supplementation with butyrate, a SCFA, was able to reduce weight gain in HFD fed mice, presumably via HDAC3 dependent mechanisms
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If no: 0% coverage probability for weight-loss indication If yes: proceed to question 5 Question 5: Have you completed required step therapy
Healthcare providers usually recommend gradual dose escalation to minimize gastrointestinal symptoms
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