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Retinol dehydrogenases use NADPH as a cofactor in the reduction of retinaldehyde to retinol and use NAD + as cofactor when oxidizing retinol to retinaldehyde
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Regarding treatment strategies, it is suggested that the marked decrease in GPx1 expression may be the major mechanism of tumor sensitization to anthracyclines [93] and that GPx1 can partially inhibit doxorubicin-induced cell death-related signaling in breast cancer by interfering with the activation of the sphingomyelin-ceramide pathway [85]
In: Erdman JWJ, Macdonald IA, Zeisel SH, eds
Chronic Kidney Disease Is Associated with Increased Plasma Levels of Fibroblast Growth Factors 19 and 21
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