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By June 2026, NIH reported data covering more than 747,000 participants, including over 535,000 whole genome sequences, describing the program as the largest integrated genomics and health database in the world ( [17] )

Transplanted stem cells and cell-derived extracellular vesicles (EVs) can effectively modulate cytokine profiles, macrophage polarization dynamics, microglial activation states, and systemic immune responses [22,23,24,25,26,27,28,29]

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