Therefore, it is urgent to clarify further whether GLP-1 RAs indeed exert a beneficial effect on DR using a novel study design or study with a large sample size
As of early 2026, the most effective GLP-1 drug for weight loss is tirzepatide (Mounjaro, Zepbound)
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Studies have proven that TLRs, MAPK, MyD88, CxCR4, PI3K/AKT, mTOR, COX-2, iNOS, Nrf2, HO-1, -enolase, STAT, AMPK, JAK, and NF-B signaling pathways are major components of NIF (248, 251, 252)
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