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However, under starvation cells increase production of mitochondrial-derived hydrogen peroxide, which has been shown to be partly dependent on the activation of class III PI3K (Scherz-Shouval and Elazar, 2007)

Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms

Its a very long story and its not feasible to explain all of it at this moment