bloody stool tirzepatide and Mucus in Stool: Causes and When to Seek Care TrimRX | Tirzepatide Diarrhea —

Dont forget to claim CE credit for this episode

Blood glucose effects should be monitored in patients with diabetes

JAMA (2022) 6

Millions have used GLP-1 drugs like Wegovy and Zepbound for weight loss and heart health

What FDA Requires for NASH Approval FDA NASH Drug Approval Criteria (Based on Past Trials): Option 1: Histological Improvement (Biopsy-Based) NASH resolution (no inflammation, no ballooning) AND no worsening of fibrosis OR Fibrosis improvement (1 stage reduction) AND no worsening of NASH Option 2: Surrogate Endpoints (If Validated) Combination of imaging + biomarkers Must correlate with clinical outcomes Requires extensive validation Retatrutide's Current Status: Phase 2a: Fat reduction proven (surrogate endpoint) Phase 3 (TRIUMPH): Liver enzymes being measured (secondary) Still needs: Dedicated NASH trial with liver biopsies Phase 3 TRIUMPH: What Liver Data Will We Get

One important antioxidant found in watermelon is glutathione , which plays a significant role in supporting egg quality