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A 2022 commentary in Wound Repair and Regeneration stated: "Fewer than 15% of compounds showing efficacy in rodent wound models achieve statistical significance in Phase III human wound trials" [8]

There's no known interaction risk between the two routes, though total copper intake should be monitored at higher combined doses

Administration Route by Peptide Type When Injectable GHK-CU Makes Sense The injectable form provides systemic benefits that topical cannot achieve: Whole-body tissue regeneration effects Internal organ support Consistent blood levels Better bioavailability Combined with other injectable peptides When Topical Makes Sense Topical application excels for: Targeted skin treatment Hair and scalp applications Those avoiding injections Combination with skincare routines Localized wound healing For maximum benefit, some protocols use both injectable GHK-CU for systemic effects and topical copper peptides for targeted skin benefits

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For example, 2 mg is equal to 2,000 mcg

S.DostertC.NonnenmacherY.CoxM.et al (2017)