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Phosphorylation of Y1135 and Y1131 destabilises the autoinhibitory conformation of the a-loop, whereas phosphorylation of Y1136 stabilises the catalytically optimised conformation of it (Favelyukis et al, 2001)

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While short-term anti-inflammatory effects can be helpful, long-term immune regulation --- especially in patients with autoimmune conditions --- needs careful monitoring

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