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Daniel Drucker [Biomarker 2023] GLP-1 agonists carry a black box warning for C-cell medullary thyroid cancer, an event that was noted in animal studies, but never in human patients in decades of clinical trials
Research findings include reductions in adiposity in animal models without changes in food intake, suggesting metabolic-shift rather than appetite-suppression mechanisms a profile distinct from GLP-1 weight loss compounds
Wollin SD, Jones PJ
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(Source: ScienceDaily, 2025) Semaglutide Delivers Major Weight Loss in Adults Over 65 A 2026 study presented at the European Association for the Study of Obesity found that older adults (65+) taking once-weekly semaglutide experienced substantial weight loss and improvements in multiple health measures with results similar to those seen in the broader STEP trial population
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