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Injecting cold semaglutide may cause stinging or cramping sensations

Protocol duration depends on individual response and injury characteristics

It should be mentioned that similar studies have been conducted on other GLP-1 receptor agonists, namely Semaglutide

However, the diffusion of molecules through the skin is the main drawback due to the characteristics of different layers of the skin, principally the stratum corneum and its barrier-like behavior

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Regarding drug delivery strategies, a cranial sustained-release system loaded with ferroptosis inhibitors (such as Ferrostatin-1) could be developed, mimicking the intravitreal injections used in AMD, to achieve localized drug release and enhance therapeutic efficacy (90)