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doi:10.1055/s-0032-1328271 [18] Crider KS, Yang TP, Berry RJ, Bailey LB

While APOE3 is the most prevalent and considered the neutral isoform, APOE2 is often associated with protective effects against neurodegeneration

Second, as a stimulant, long-term use is generally avoided to prevent potential strain on the cardiovascular system and to minimize the risk of dependency

Original Study Reference Kuceki G, Coppinger AJ, Ragi SD, Johnson LS, Goren A, Kalil LL, Cirino P, Wambier CG