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Recently, both the receptors have shown to heteromerize in vitro , eliciting synergistic signaling and -arrestin-2 recruitment (300)

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The FDA also granted Breakthrough Therapy Designation to Trodelvy (sacituzumab govitecan-hziy) for the treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC) whose disease has progressed on or after platinum-based chemotherapy