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doi: 10.3390/ijms222212403 35 ConradMPrattDA
Collectively, the synergistic action of AGE-RAGE signaling, metabolic rewiring, and oxidative stress in the DW microenvironment creates a powerful, self-reinforcing circuit that locks macrophages into a persistent M1 state, thereby perpetuating chronic inflammation and impeding the resolution of healing (Figure 3)
Further speeding up adoption are rising awareness of lifestyle-related illnesses and increased acceptance of GLP-1 treatments for conditions other than diabetes, such as obesity
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