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PMID: 40691175 Nat Commun 2022 Jun 17;13(1):3486

The mechanisms underlying cancer drug resistance are complex and multifactorial, including alterations in drug targets, increased drug efflux through transporters such as ATP-binding cassette family, drug inactivation, changes in the cell cycle, and evasion of apoptotic pathways through downregulation of pro-apoptotic proteins like BCL2-associated X [13]

PLoS One 10, e0127086 (2015)

At the same time, there are significant opportunities that could accelerate progress and widen its therapeutic scope

Diarrhoea may occur in some individuals, particularly with higher-dose supplements

Axonemal doublet microtubules can split into two complete singlets in human sperm flagellum tips