1810): glucagon receptors also couple to Gi protein in human atrial myocytes, and Gi upregulation in the cardiomyocyte inhibits cAMP formation and Gs-coupled signal transduction, so glucagon action in the chronically failing heart "may theoretically be impaired." Two limits on how far that carries: the condition Petersen describes is heart failure , not obesity or sedentary metabolic dysfunction, and the impairment is offered as a hypothesis, not an observation
#Pharmacy #ClinicalPharmacy #Obesity #WeightManagement #GLP1 #Tirzepatide #Semaglutide #Liraglutide #EvidenceBasedMedicine #MedicalEducation To view or add a comment, sign in New publication: rethinking treatment for obesity and type 2 diabetes Excited to share a new review article, "Obesity and Type 2 Diabetes: One Injection, Two Conditions," by Adapa harika Adapa and Peivand Pirouzi, Ph.D
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