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When combined with GLP-1 medications like semaglutide or tirzepatide, coaching ensures youre preserving muscle, fueling strength, and setting yourself up for long-term transformation, not another yo-yo cycle

These drugs mimic the physiological effects of GLP-1 by binding to GLP-1R, which enhances insulin secretion, inhibits glucagon release, delays gastric emptying, and reduces food intake (Figure 1B)

The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

A reasonable progression involves adding 10 to 15% to weekly mileage when the previous weeks training produced no significant flare-ups

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