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PubMed Central , doi:10.1016/j.coph.2007.04.005
Of these genes, EtOH feeding up-regulated Fads1 and down-regulated Acox1 genes in WT mice, a result in agreement with the observed increase in total TG content
While some studies suggest a potential link between the two, others have not found direct evidence supporting osteoporosis as a causative factor in lowering serum albumin levels
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Preclinical data have not shown prominent adverse effects, but human safety data are limited
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