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In the SUSTAIN-6 study, which compared subcutaneous semaglutide to placebo, DR complications occurred in 3% of semaglutide and 1.8% of placebo subjects
10.1038/s41467-023-44067-4 34 KanmaniP.VillenaJ.LimS.-K.SongE.-J.NamY.-D.KimH
It was found that meta-substitution of the phenyl ring with a sulfamoyl group enhanced the DPP-4 inhibitory activity of the lead compound 56 (Figure 7)
Patients with a history of thyroid cancer should discuss semaglutide use with their oncologist, as GLP-1 agonists are relatively new in this population