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She states that in one of her published Phase 2 clinical trials, 100% of subjects receiving retatrutide experienced significant weight loss at doses of 8 mg/week and 12 mg/week

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332,333,334 Specifically, IR leads to compensatory hyperinsulinemia, which stimulates GnRH gene transcription through MAPK pathway in PCOS and increases LH pulse secretion, thereby significantly increasing ovarian androgen synthesis

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