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In this model, the PH and C2 domains operate in concert as a "tether and fix" apparatus necessary for processive catalysis by the enzyme

Protein concentrations were determined using the BCA assay, and samples were adjusted to equal concentrations before denaturation

Reduction of Hedonic Eating Signals: By acting on the brains reward centers, GLP-1 diminishes the pleasure response associated with high-calorie foods

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Participants received tirzepatide or placebo for 72 weeks (Jastreboff et al., NEJM 2022)

Withdrawing a smaller or larger aliquot changes the absolute mass of every component simultaneously, but the ratio between them stays locked at 5:1:1:1