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Both GIPR co-agonism (as in tirzepatide) and GIPR antagonism (as in MariTide, a bispecific hybrid molecule comprising two GLP-1R agonist peptides conjugated to a monoclonal anti-GIPR antagonistic antibody) are effective in treating people living with obesity 2,3,22
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The gut adaptation to GLP-1 medications sometimes manifests as loose stools or increased bowel frequency
Following the recommended titration schedule and implementing dietary modifications can help minimise these effects and optimise treatment response
The pills contain salcaprozate sodium, which helps protect the active ingredients from stomach acids and allows absorption across the stomach lining, Jaisinghani explains
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