off-label use of glp-1 agonists for obesity in 2016 Genetics: How Genes Affect Appetite, Semaglutide, and Tirzepatide Response Frontiers | Clinical perspectives on

Its concurrent engagement of GLP-1R, GIPR, and GCGR distinguishes it structurally and pharmacologically from both selective GLP-1R agonists such as semaglutide and dual GLP-1R/GIPR agonists such as tirzepatide

If it is, you will get a letter in the mail saying you are approved

Additionally, there are indirect factors influencing TJs, such as matrix metalloproteinases (MMPs), NO, ROS, Rho-associated protein kinase (ROCK), and NF-B signaling pathways [120,121,122,123,124]

The appropriate dose will depend on the patients individual needs

However, there is currently very little direct evidence on this (further discussion here)

Weber MA, Mansfield TA, Alessi F, Iqbal N, Parikh S, Ptaszynska A