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Medical Consensus: High Serum B12 in Supplementers is Safe The medical community broadly agrees that high serum B12 levels resulting from supplementation are safe for individuals with no underlying health issues
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Most experienced users recommend starting at 0.25 mg daily for the first week, then increasing to 0.5 mg daily if well tolerated and additional benefit seems likely
doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois
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