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The authors hypothesized that early life adversity may alter oral microbiome composition, which can shift to gut via saliva, potentially creating a pro-inflammatory state that increases vulnerability to PTSD following subsequent trauma exposure (Malan-Muller et al., 2022)

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These follow-on patents provide patent protections until 2042.15 This is an additional ten years beyond the main compound patent for semaglutide, which has already benefited from an additional five year extension (Figure 8)

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