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For instance, in NSCLC, treatment with first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) often leads to the development of the EGFR T790M mutation, while third-generation inhibitors subsequently select for the C797S mutation, both of which confer resistance
10.1111/acel.12427 25 PaulK.AntonB
Potential side effects are generally mild (e.g., bloating or digestive upset) when taken in recommended doses
Reported Side Effects The most commonly reported side effects are mild and transient: Injection site reactions: Mild redness, itching, or discomfort at injection sites affects a small percentage of users
[16] These remain areas of investigation in humans and should not be interpreted as established risks at this stage
AOD-9604 received FDA GRAS (Generally Recognized As Safe) status as a food ingredient in 2007, but this is not drug approval
