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The barrel is narrow and the markings are close together, which means each graduation is visible and easy to read at very small volumes

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Constipation can last up to 45 days during dose escalation, often longer than nausea or diarrhea, which typically resolve within one to two weeks

doi: 10.1001/jama.2016.17441 25 NegroMMarzulloNCasoFCalanni PirelliLDAntonaG

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