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This family of bacteria are able to metabolize primary bile acids into secondary bile acids, which then bind to TGR5 and stimulate GLP-1 secretion ( Akkermansia muciniphila significantly increases the ileal expression of Gcg and Pcsk1 , and oral glucose-stimulated plasma GLP-1 compared to mice fed the HFD alone (Yoon et al., 2021)
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(B-F) After 24h in culture with either 250uM melatonin or vehicle control the concentrations of IL-5 (B), IL-13 (C) , IL-9 (D) IL-10 (E) , and IL-6 (F) was determined by LEGENDPlex assay
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GPX1 is one of the most abundant members of the GPX family of enzymes
This mechanism has particularly important implications for wound healing research
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