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Senescent hepatocytes are more abundant in patients with MAFLD and, as observed in other chronic liver diseases, their senescence levels correlate with the severity of MAFLD, as confirmed by liver biopsies in these patients (136)

By integrating biomarker profiles with genetic susceptibility and exposure history, future studies may develop predictive models that could implement targeted surveillance and preventive interventions tailored to the unique biological impact of occupational circadian disruption 273

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