You can mix your collagen powder into a drink and take your glutathione capsule at the same time without worrying about wasting your money
According to reports, serious allergic reactions, liver damage, kidney stress, peripheral nerve damage, and even systemic inflammatory response syndrome (SIRS) can happen after getting a glutathione shot
But an overactive transsulfuration pathway also has a trade-off: it can pull methyl groups and sulfur amino acids away from the methylation cycle, sometimes increasing the need for B6 and molybdenum to keep downstream detox pathways balanced
doi:10.1016/j.plefa.2009.10.002, PMID: 19906518 Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ (2005) Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms
Notably, the expression of multiple GSTs is massively activated by salicylic acid and some GST enzymes were demonstrated to be receptor proteins of salicylic acid
Gentle swirling is acceptable, but shaking can denature the peptide and reduce potency