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A hallmark of ferroptotic initiation and execution is the upregulated peroxidation of phospholipid-bound polyunsaturated fatty acids (PUFAs) within cellular membranes, a process facilitated by labile iron pools (LIPs) and amplified through autocatalytic radical reactions (13,14)

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So, while branded Mounjaro and Wegovy may be roughly equal in terms of convenience, Wegovys base ingredient semaglutide is more readily available and easier to take

The therapeutic objective will thus shift from maximal cytoreduction toward achieving a functional cure and durable, immunemediated disease control that ensures longterm survival despite minimal residual disease