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If you suffer from preexisting allergies, medical conditions, heart failure, or if you are taking other prescription medications (especially for heart conditions) it is highly important to discuss this with your doctor prior to taking B12 supplements

Rhonda Patrick adds: "NAD+ precursors like NMN increase levels, aiding DNA repair and energykey for anti-aging."[34] She suggests stacking with NNMT inhibitors for sustained effects

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the methyl group at the 1-position and the amino group at the 5-position appear important for inhibitory activity