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16,51 The anxiolytic effect of GLP-1 agonists has been hypothesized due to the preservation of brain-derived neurotrophic factor/nuclear factor erythroid 2related factor 2 levels, decreased oxidative stress, and lipocalin 2 levels in the hippocampus

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To facilitate the CEA, the NNT measures were only estimated for the statistically significant clinical outcomes between study groups: all-cause death (HR [95% CI]: 0.40 [0.18, 0.91]) and hospitalized hypoglycemia (0.43 [0.27, 0.69])

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