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The presence of alternative SELENOP-independent transport pathways for Se was identified in the early studies in Selenop / mice fed Se sufficient diet (Hill et al., 2003

Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, Kovacs A, Han X, Gross RW, Kozak R, Lopaschuk GD

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The temptation is to skip the low-dose titration phase, reasoning that GLP-1 receptor adaptation has already occurred

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