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It works by reducing appetite, slowing digestion, increasing calorie burn, and improving insulin sensitivity, creating a comprehensive metabolic shift that supports sustained fat loss
After stopping the drug, approximately 97% clears within 30 days (five half-lives)
this was particularly evident for patients treated with once-weekly GLP-1 RAs at 12 months post-index, where a mean weight loss of 2.8 kg (95% CI 3.6, 2.1) was reported for adherent patients, whereas poor adherence was associated with a weight gain of 0.2 kg ( 0.5, 0.9) (Supplemental Fig
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Crohn's disease is not explicitly listed as a contraindication to semaglutide use in the FDA prescribing information
