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Additionally, ghrelin administration has been found to increase food consumption in some individuals, although further research is needed to fully understand its effects

Clinicians should monitor patients for potential adverse effects including pancreatitis (severe, persistent abdominal pain), gallbladder disease (right upper quadrant pain), diabetic retinopathy complications (especially with rapid glucose improvement), acute kidney injury with dehydration, and hypoglycemia when combined with insulin or sulfonylureas

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Furthermore, higher levels of PUFAs in cellular membranes due to diets high in unsaturated fatty acids enhance the susceptibility to LPO especially under conditions of vitamin E deficiency