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In REDEFINE 1, cagrilintide 2.4 mg alone over 68 weeks produced a 11.5% mean body-weight change versus 3.0% with placebo (treatment-policy estimand) roughly half the combinations 20.4%

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A research finding in an animal model is not the same as an approved human treatment protocol

This works by temporarily blocking nerve signals to the muscles which will prevent the facial muscles from contracting when making expressions